The
disease is also a metabolic disorder of the disaccharide lactose. Lactose
in the gastrointestinal tract is broken down by the enzyme lactase into glucose
and galactose. In
people with lactose intolerance disease there is a deficiency of the enzyme
lactase, for reducing its synthesis or not synthesized at all. Defect
here lies in the mechanism for the synthesis of this enzyme, which stem from
abnormalities in the gene codon.
These
codon changes caused the enzyme lactase is not synthesized or synthesized in
insufficient amounts. As
a result, can not digest lactose and lactose levels are high enough in the
digestive tract works as laxans, causing diarrhea. Symptoms
that occur are that this disease will suffer from diarrhea if given breast milk
or milk products, either breast milk or cow's milk or other animal.
Because
the fault lies in the genes, it is clear that the disease is inherited
(hereditary), and since the child was born there. The
disease is also mainly found among the adults who usually do not consume milk. In
these people may be small when it does not suffer from the disease, but is
formed after becoming an adult. In
this case there is no disease is congenital, but after gradually become mature.
Adults
who since childhood continue to consume milk or water uses in food, in general
do not suffer from the disease. Concluded
that the disease obtained in adults is an adaptation of the body, because there
is no substrate to be processed (lactose), the enzyme is not needed anymore, so
the body gradually remove the capacity to make the enzyme lactase.
Formerly
the disease lactose intolerance in children considered to be caused by
infection through equipment that is less clean, but then it turns out the use
of milk equipment (bottles, rubber nipples, etc.) are quite clean though still
give diarrhea. With
advances in the field of nutrition research, then note that the diarrhea was
caused by not resistant to nutritional components contained in milk, i.e.
lactose.
Therapy
and prevention it is the provision of low-lactose milk (LLM = Low Lactose Milk)
or by replacing milk with soy milk does not contain lactose. This
treatment should be done all his life, because it does not change the
conditions of the enzyme is deficient.
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